Oxidative stress development is determined on the basis of the glucocorticoid-induced oxidative stress model in the laboratory pregnant animals. It is proved by the methods of morphological and histochemical analysis that the embryo axial skeleton formation time slows in the pregnant females with high content of the free-radical lipid peroxidation products in blood plasma. Combined use of the glucocorticoids and thiophane antioxidant in gestation reduces the oxidative stress indicators in the pregnant rat blood plasma to the physiological mean level and optimizes the rat fetus axial skeleton morphogenesis.
rats, pregnancy, oxidative stress, thiophane antioxidant, chondroblasts, vertebral body, rat fetuses
1. Abramchenko V.V. Antioksidanty i antigipoksanty v akusherstve. - SPb., 2001. - 400 s.
2. Akker L.V., Varshavskiy B.Ya. Pokazateli oksidantnogo i antioksidantnogo statusa u beremennyh s gestozom // Akusherstvo i ginekologiya - 2000. - № 4. - S. 17-20.
3. Afanas'eva N.V., Strizhakov A.N. Ishody beremennosti i rodov pri fetoplacentarnoy nedostatochnosti razlichnoy stepeni tyazhesti // Voprosy ginekologii, akusherstva i perinatologii. - 2007. - T. 3, № 2. - C. 7-13.
4. Pokazateli processa degradacii belkov i antiokislitel'noy sistemy pri normal'noy beremennosti / S.O. Burmistrov [i dr.] // Akusherstvo i ginekologiya. - 2001. - № 6. - S. 17-20.
5. Gromyko G.L., Shpakov A.O. Sovremennye predstavleniya o mehanizmah regulyacii krovoobrascheniya v placente pri fiziologicheskoy i oslozhnennoy beremennosti // Vestn. Ros. associacii akusherov-ginekologov. - 1995. - № 4. - C. 35-41.
6. Evsyukova I.I., Savel'eva T.V. Svobodnoradikal'noe okislenie u donoshennyh novorozhdennyh detey s razlichnoy patologiey // Pediatriya. - 2005. - № 1. - S. 13-16.
7. Ziganshina L.E., Burnasheva Z.A., Valeeva I.H. Sravnitel'noe izuchenie effektivnosti dimefosfona i ksidofona pri steroidnom osteoporoze u krys // Eksperimental'naya i klinicheskaya farmakologiya. - 2002. - № 6. - S. 55-56.
8. Korolyuk M.A. Metod opredeleniya aktivnosti katalazy // Lab. delo. - 1988. - № 1. - S. 16-19.
9. Okislitel'nyy stress: Patologicheskie sostoyaniya i zabolevaniya / E.B. Men'schikova [i dr.]. - Novosibirsk: ARTA, 2008. - 284 s.
10. Opredelenie rezistentnosti k okisleniyu lipoproteinov nizkoy plotnosti syvorotki krovi: metod. rekomendacii / sost. Yu.I. Ragina, M.I. Dushkin. - Novosibirsk, 1998. - 11s.
11. Pavlova V.N. Hryasch. - M.: Medicina, 1988. - 320 s.
12. Stal'naya I.D. Sovremennye metody v biohimii. - M.: Medicina, 1977. - 391 s.
13. Chesnokova N.P., Ponukalina E.V., Bizenkova M.N. Molekulyarno-kletochnye mehanizmy indukcii svobodnoradikal'nogo okisleniya v usloviyah patologii // Sovremennye problemy nauki i obrazovaniya. - 2006. - № 6 - S. 21-26.
14. Onset of maternal arterial blood flow and placental oxidative stress; apossible f actor in human early pregnancy failure / E. Jauniaux [et al.] // Am. J. Pathol. - 2000. - Vol. - 157. - P. 2111-2122.
15. Laihia J.K., Jansen C.T. Lucigenin and linoleate enhanced chemiluminescent assay for superoxide dismutase activity // Free Radic. Biol. Med. - 1993. - Vol. 14. - P. 457 -461.
16. Sharma J.B., Sharma A., Bahadur A. Oxidative stress markers and antioxidant levels in normal pregnancy and pre-eclampsia // International Journal of Gynecology and Obstetrics. - 2006. - Vol. 94. - R. 23-27.
