Doxorubicin cytotoxic influence in mice bone marrow cells in vitro and in vivo that is registered according to the plasma membrane blebbing induction and cells apoptosis, cultivated in diffusion chambers is researched.
mouse, bone marrow, condition, blebbing, apoptosis, doxorubicin
1. Gol'dberg E.D., Novickiy V.V. Protivoopuholevye antibiotiki antraciklinovogo ryada i sistema krovi. - Tomsk: Izd-vo Tom. un-ta, 1986. - 240 s.
2. Indukciya apoptoza v kletkah kostnogo mozga oposreduetsya aktivnost'yu purinergicheskih receptorov / Yu.A. Uspenskaya [i dr.] // Byul. eksperim. biologii i mediciny. - 2004. - T. 138. - № 8. - S. 135-138.
3. Uspenskaya Yu.A., Salmina A.B. Rol' narusheniy ekspressii konneksinov v razvitii apoptoza kletok kostnogo mozga pri deystvii mielotoksicheskogo ksenobiotika // Sib. med. zhurn. - 2007. - № 1. - S. 51-54.
4. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity / G. Minotti [et al.] // Pharmacol. Rev. - 2004. - Vol. 56. - P. 185-229.
5. Charras G.T. A short history of blebbing // J. Microsc. - 2008. - Vol. 231. - № 3. - P. 466-478.
6. Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines / J.M. Dypbukt [et al.] // J. Biol. Chem. - 1994. - Vol. 269. - № 48. - P. 30553-30560.
7. Doonan F., Cotter T.G. Morphological assessment of apoptosis // Methods. - 2008. - Vol. 44. - № 3. - P. 200-204.
8. Gough N.R. When repair is suicide // Sci. Signal. - 2009. - Vol. 2. - № 85. - P. 283.
9. Hagmann J., Burger M.M., Dagan D. Regulation of plasma membrane blebbing by the cytoskeleton // J. Cell Biochem. - 1999. - Vol. 73. - № 4. - P. 488-499.
10. Involvement of p38 in apoptosis-associated membrane blebbing and nuclear condensation / R.G. Deschesnes [et al.] // Mol. Biol. Cell. - 2001. - Vol. 12. - № 6. - P. 1569-1582.
11. Lane J.D., Allan V.J., Woodman P.G. Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells // J. Cell Sci. - 2005. - Vol. 118. - P. 4059-4071.
12. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I / M.L. Coleman [et al.] // Nat. Cell Biol. - 2001. - Vol. 3. - № 4. - P. 339-345.
13. Shiratsuchi A., Mori T., Nakanishi Y. Independence of plasma membrane blebbing from other biochemical and biological characteristics of apoptotic cells // J. Biochem. - 2002. - Vol. 132. - P. 381-386.