THE INFLUENCE OF PREPARATION AND EXPERIMENT CONDUCTING CONDITIONS ON THE FUNCTIONING CHARACTERISTICS OF THE ISOLATED PERFUSED RAT LIVER
Rubrics: EKOLOGIYA
Abstract and keywords
Abstract (English):
The effect of the perfusion conditions (duration of the preparatory period, noradrenaline and lactic acid) on the characteristics of isolated rat liver functioning is determined in the present research.

Keywords:
isolated liver perfusion, metabolism, noradrenaline, gluconeogenesis, hypoxia
Text
Text (PDF): Read Download
References

1. Alexander H.R.Jr., Butler C.C. Development of isolated hepatic perfusion via the operative and percutaneous techniques for patients with isolated and unresectable liver metastases // Cancer. - 2010. - Vol. 16, № 2. -P. 132-141.

2. Participation of the liver gluconeogenesis in the glibenclamide-induced hypoglycaemia in rats / S.A. Geisler [et al.] // Cell Biochem. Funct. - 2011. - Vol. 29, № 2 - P. 81-86.

3. Gerrit van Hall. Lactate kinetics in human tissues at rest and during exercise // Acta Physiol. - 2010. - Vol. 199, № 4 - P. 499-508.

4. Gladden L.B. Lactate metabolism: a new paradigm for the third millennium // J Physiol. - 2004. - Vol. 558, № 1 - P. 5-30.

5. Jitrapakdee S. Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis // Int. J. Biochem. Cell Biol. - 2012. - Vol. 44, № 1 - P. 33-45.

6. Targeted gene delivery to selected liver segments via isolated hepatic perfusion / H. Kinoshita [et al.] // J Surg Res. - 2010. - Vol. 160, № 1 - P. 47-51.

7. Induced hypoglycemia for 48 hours indicates differential glucose and insulin effects on liver metabolism in dairy cows / L. Kreipe [et al.] // Journal of Dairy Science (JDS). - 2011. - Vol. 94, № 11 - P. 5435-5448.

8. Role of oxygen during hypothermic machine perfusion preservation of the liver / B. Lüer [et al.] // Transplant International. - 2010. - Vol. 23, № 9. - P. 944-950.

9. Molecular regulation of lipid metabolism in liver and muscle of rainbow trout subjected to acute and chronic insulin treatments / S. Polakof [et al.] // Domestic Animal Endocrinology. - 2010. - Vol. 39, № 1. - P. 26-33.

10. Sharize Betoni Galende et al. Glucose administration inhibits the hepatic activation of gluconeogenesis promoted by insulin-induced hypoglycemia // Braz. Arch. Biol. Technol. - 2009. - Vol. 52, № 4. - P. 849-854.

11. Sharma A.M., Staels B. Peroxisome proliferator-activated receptor y and adipose tissue-understanding obesity-related changes in regulation of lipid and glucose metabolism // J. Clin. Endocrinol. Metab. - 2007. - Vol. 92, № 2. - P. 386-395.

12. Rupenko A.P., Kruglik O.V., Morgulis I.I. Funkcional'naya aktivnost' izolirovannoy perfuziruemoy pecheni zavisit ot sostava sredy // Byul. eksperimental'noy biologii i mediciny. - 2008. - T. 146, № 7 - C. 117-120.

13. Rupenko A.P., Kruglik O.V., Morgulis I.I. Snabzhenie pecheni kislorodom v usloviyah izolirovannoy perfuzii // Dokl. Akademii nauk. - 2008. - T. 418, № 1. - C. 128-130.


Login or Create
* Forgot password?