The methods of the nano-selenium synthesis using stabilizers of different nature are considered in the article. The comparative data of selenium various form toxicity: nano-selenium, sodium selenite and methyl-selenium-cysteine are given. It is shown that the nano-selenium preparations have significantly less toxicity than the known selenium preparations.
nano-selenium, toxicity
1. Veterinarnaya toksikologiya s osnovami ekologii: ucheb. posobie / pod red. M.N. Argunova. - SPb.: Lan', 2007. - 416 s.
2. Georgievskiy V.I., Annenkov P.N., Samohin V.T. Mineral'noe pitanie zhivotnyh. - M.: Kolos, 1979. -471 s.
3. Zaycev S.Yu., Konopatov Yu.V. Biohimiya zhivotnyh. Fundamental'nye i klinicheskie aspekty: ucheb. -SPb.: Lan', 2004. - S. 271-272.
4. Pat. 2485964 Ros. Federaciya: kl.A61 K35/20; A61K33/04; A61P37/02; B82B1/00. Immunostimuliruyuschaya kompoziciya dlya zhivotnyh / S.V. Kozlov, V.S. Stepanov, A.S. Fomin [i dr.]. - Zayaviteli i patentoobladateli S.A. Staroverov, A.A. Volkov. - 2012100596/15; zayavl. 10.01.2012; opubl. 27.06.2013, Byul № 18. - 1 s.
5. Pat. 2250099 Ros. Federaciya: MPK7kl. A61K009/08; A61K033/04; A61K031/07; A61K035/78. Kompleksnyy preparat semakur-A / A.B. Samoryadova, E.N. Vergeychik. - Zayaviteli i patentoobladateli OOO «BioTEP». - 2002132915/15; zayavl. 06.12.2002; opubl. 20.04.2005, Byul. № 11. - 2 s.
6. Pat.2392944 Ros. Federaciya MPK6kl A61K031/785; A61K033/04; A61R003/02. Preparat dlya lecheniya i profilaktiki narusheniya obmena selena dlya sel'skohozyaystvennyh zhivotnyh / V.A. Orobec, A.V. Serov, V.A. Belyaev [i dr.]. - Zayaviteli i patentoobladateli FGBOU VPO «Stavropol'skiy gosudarstvennyy agrarnyy universitet». - 2008137463/15; zayavl. 18.09.2008; opubl. 27.06.2010. - 2 s.
7. Reshetnik L.A., Parfenova E.O. Biogeohimicheskoe i klinicheskoe znachenie selena dlya zdorov'ya cheloveka // Sib. med. zhurn. - 1999. - T. 18, № 3. - S. 16-22.
8. Rukovodstvo po eksperimental'nomu (doklinicheskomu) izucheniyu novyh farmakologicheskih veschestv / pod obsch. red. R.U. Habrieva. - 2-e izd., pererab. i dop. - M.: OAO «Izdatel'stvo «Medicina», 2005. - 832 s.
9. Pat. 2242234 Ros. Federaciya MPK7 kl. A61K033/04; A61K035/78; A61R037/02. Sposob polucheniya nano-molekulyarnogo selenoproteina, obladayuschego immunotropnym i metabolicheskim deystviem / Yu.A. Novickiy, M.Yu. Novickiy. - Zayaviteli i patentoobladateli Yu.A. Novickiy, M.Yu. Novickiy. -2003136035/15; opubl. 20.12.2004.
10. Novyy biologicheski aktivnyy preparat na osnove nanochastic selena / A.G. Hramcov, A.V. Serov, V.P. Timchenko [i dr.] // Vestnik Sev-KavGTU. - 2010. - № 4 (25).
11. Henning A. Mineral'nye veschestva, vitaminy, biostimulyatory v kormlenii sel'skohozyaystvennyh zhivotnyh / per. s nem. N.S. Gel'man; pod red. A.L. Paduchevoy, Yu.I. Raeckoy. - M.: Kolos, 1976.
12. Baughman T.A. Elemental mercury spills // Environmental Health Perspectives. - 2006. - Vol. 114. - P. 147-152.
13. Celo V., Lean D.R.S., Scott S.L. Abiotic methylation of mercury in the aquatic environment // Science of the Total Environment. - 2006. - Vol. 368. - P. 126-137.
14. Clarkson T.W., Magos L., Myers G.J. The toxicology of mercury--current exposures and clinical manifestations // N Engl J Med. - 2003. - Vol. 349. - P. 1731-1737.
15. Corazza A., Boffito C. Mercury dosing solutions for fluorescent lamps // Journal of Physics D-Applied Physics. - 2008. - Vol. 41.
16. Eckelman M.J., Anastas P.T., Zimmerman J.B. Spatial Assessment of Net Mercury Emissions from the Use of Fluorescent Bulbs // Environmental Science & Technology. - 2008. - Vol. 42. - P. 8564-8570.
17. Engelhaupt E. Do compact fluorescent bulbs reduce mercury pollution? // Environmental Science & Technology. - 2008. - Vol. 42. - P. 8176-8176.
18. Garnett M.C., Kallinteri P. Nanomedicines and nanotoxicology: some physiological principles // Occupatinal Medicine-Oxford. - 2006. - P. 307-311
19. Gilbert S.G., Grantwebster K.S. Neurobehavioral Effects of Developmental Methylmercury Exposure // Environmental Health Perspectives. - 1995. - Vol. 103. - P. 135-142.
20. Griffiths C., McGartland A., Miller M. A comparison of the monetized impact of IQ decrements from mercury emissions // Environ Health Perspect. - 2007. - Vol. 115. - P. 841-847.
21. Reduction of mercury loss in fluorescent lamps coated with thin metaloxide films / V.D. Hildenbrand, C.J.M. Denissen, A.J.H.P. Van der Pol [et al.] // Journal of the Electrochemical Society. - 2003. - Vol. 150. -P. H147-H155.
22. Jang M., Hong S.M., Park J.K. Characterization and recovery of mercury from spent fluorescent lamps // Waste Management. - 2005. - Vol. 25. - P. 5-14.
23. Mercury vapor release from broken compact fluorescent lamps and in situ capture by new nanomaterial sorbents / N.C. Johnson, S. Manchester, L. Sarin [et al.] // Environmental Science & Technology. - 2008. - Vol. 42. - P. 5772-5778
24. Psychological effects of low exposure to mercury vapor: application of a computer-administered neurobehavioral evaluation system / Y.X. Liang, R.K. Sun, Y. Sun [et al.] // Environ Res. - 1993. - Vol. 60. - P. 320-327
25. Love Sarin. Nano-Selenium: Novel Formulations for Biological and Environmental Applications A Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy In the Division of Engineering at Brown University Providence, Rhode Island. - May 2010
26. Nel A., Xia T., Madler L. Toxic potential of materials at the nanolevel // Science Magazine. - 2006. - Vol. 311. - P. 622-627
27. Ralston N. Nanomaterials: Nano-selenium captures mercury // Nature Nanotechnology. - 2003. - Vol. 3. -P. 527-528
28. Smith I., Hogan J. Vitamin E and selenium can help lover incident of mastitis // Zarge anim. Veter. - 1988. 43, 6. - R. 20-24
29. Spasic M.B., Spasic Z.S., Buzadzic B. Effect of term exposure to cold on the antioxidant defense system in the rat // Free Rad. Biol. Med. - 1993. - № 3. - P. 291-299
30. Zhang J., Wang X., Xu T. Elemental selenium at Nano Size (Nano-Se) as a potential chemopreventive Agent with reduced risk of selenium toxicity: comparison with Se-Methelselenocysteine in mice // Toxicological sciences. - 2008. - № 101 (1). - P. 22-30
