The study of the antineoplastic activity of the nano-preparation “Selenium” applied in various doses in 40 non-purebred mice with the intertwined intra-abdominal-ascite carcinoma of Ehrlich is carried out. The ascite liquid volume, the tumor cell quantity in 1 ml, the life duration, the extent of tumor growth inhibition and the increase in life duration at the intra-abdominal introduction of the nanocomposite “Selenium” in the single introduction in 24 hours after a re-inoculation were assessed. The effects were compared to the ascite carcinoma of Ehrlich. The antineoplastic action of the nano-preparation “Selenium” was noted. The perspective of the further research of the nanocomposite “Selenium” for the purpose of application as the antineoplastic preparation is proved.
arabinogalactan, nano-preparation “Selenium”, ascite carcinoma of Ehrlich, reinoculation, mice, cells
1. Galaktany i galaktansoderzhaschie polisaharidy vysshih rasteniy / A.G. Arbuzov [i dr.] // Himiya prirodnyh soedineniy. - 2000. - № 3. - S. 185-197.
2. Karpova E.A. Morfofunkcional'nye izmeneniya v pecheni pri toksicheskom porazhenii i pri ego korrekcii: dis.. kand. vet. nauk. - Irkutsk, 2014. - 133 s.
3. Lamazhapova G.P. Morfologiya organov immunogeneza nerpy baykal'skoy i eksperimental'naya ocenka effektivnosti ee lipidov pri razlichnyh patologiyah: dis.. d-ra biol. nauk. -Ulan-Ude, 2011. - 209 s.
4. Medvedev Yu.V., Tolstoy A.D. Gipoksiya i svobodnye radikaly v razvitii patologicheskih sostoyaniy organizma. - M.: Terra-Kalender i Promoushn, 2000. - 232 s.
5. Medvedeva S.A., Aleksandrova G.P., Tancyrev A.P. Gel'-pronikayuschaya hromatografiya arabinogalaktana // IVUZ. Lesnoy zhurnal. - 2002. - № 6. - S. 108-114.
6. Novyy biologicheski aktivnyy preparat na osnove nanochastic selena / A.G. Hramcov [i dr.] // Vestn. SevKavGTU. - 2010. - № 4 (25). - S. 122-125.
7. Ponder G.R. Arabinogalactan from Western larch. Part III. Alkaline degeneration revisited, with novel conclusions on molecular structure // Carbohydrate Polymers. - 1997. - Vol. 34. - № 4. - P. 251-261.
8. Ueda H.A., Yamazaki C., Yamazaki M. Hydroxyl group of flavonoids affect oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production // Biosci. Biothechnol. Biochem. -2004. - Vol. 68. - № 1. - P. 119-125.
9. Willfor S., Holmbon B. Isolation and characterization of water-soluble arabinogalactans from the heartwood of Norway spruce and Scots pine // Proc. 10 Int. Symp. Wood Pulp. Chem., Yokohama, Japan. - 1999 - Vol. 2. - P. 32-34.
