Russian Federation
Russian Federation
Bovine viral diarrhea, the illness of mucous membranes of cattle is widespread in many coun-tries of the world and it is considered to be the most important disease having economic value for mod-ern animal husbandry. One of the main instruments of the fight against this infection is vaccination of animals. It allows preventing sharp disease out-breaks and embryonic mortality of a fetus, but not persistent and subclinical forms of an infection in calves. A big variety of types and subtypes estab-lished now at the virus demands creation of more effective vaccines and search of various prepara-tions and chemical compounds with the expressed antiviral activity. Now there are no effective antiviral preparations for treatment of various forms of this disease in cattle. The results of studying the effi-ciency of a new preparation concerning the causa-tive agent of viral diarrhea illness of mucous mem-branes of cattle received when carrying out the re-searches in vivo in naturally infected calves with a subclinical form of an infection are presented. When performing the study clinical, hematologic, virologic and serologichesky methods of research-es are used. The experiments were made in the calves of 3-4 months of age who are naturally in-fected with the virus with a subclinical form of an infection. The effective dose of a preparation which made 0.5 mg/kg of body weight was defined. Intranazal introduction of the preparation in this dose daily for 10 days led to the reduction of terms of allocation of the virus with nasal secrets, normal-ization of clinical condition of animals, body tem-perature and hematologic indicators. The results of serological researches of pair tests of serum of blood retrospectively confirmed etiologic role of a virus in the development in calves of a subclinical form of infection.
high-polymeric RNA, pathogen of bovine viral diarrhea-mucosal disease, cattle
1. Rasprostranenie infekcionnogo rinotra-heita i virusnoy diarei-bolezni slizi-styh obolochek krupnogo rogatogo skota v razlichnyh regionah Rossii / K.P. Yurov, A.F. Shulyak [i dr.] // Tr. VIEV. - 2003. - № 73. - S. 15-22.
2. Ridpath J.F. Bovine viral diarrhea virus: global status // Veterinary Clinics Food Animal Prac-tice. - 2010. - № 26. - P. 105-121.
3. Rasprostranenie virusnyh respiratornyh bolezney krupnogo rogatogo skota / A.G. Glotov, O.G. Petrova, T.I. Glotova [i dr.] // Veterinariya. - 2002. - № 3. - S. 17-21.
4. Deregt D., Loewen K.G. Bovine viral diar-rhea virus: biotypes and disease // Can. Vet. J. - 1995. - Vol. 36 (6). - R. 71-78.
5. Numerical taxonomy of the genus Pestivirus: new software for genotyping based on the pal-indromic nucleotide substitutions method / M. Giangaspero, C. Apicella , R. Harasawa [et al.] // J. Virol. Methods. - 2013. - Vol. 192 (1-2). - P. 59-67.
6. Giangaspero M., Harasawa R. Characteriza-tion of genotypes among bovine viral diarrhea virus type 1 strains according to palindromic nucleotide substitutions in the genomic 5'-untranslated region // J. Virol. Methods. - 2014. - Vol. 195. - P. 34-53.
7. Evermann J.F., Ridpath J.F. Clinical and epi-demiologic observations of bovine viral diar-rhea virus in the northwestern United States // Vet Microbiol. - 2002. - Vol. 89 (2-3). - P. 129-139.
8. Muñoz-Zanzi C.A., Thurmond M.C., Hietala S.K. Effect of bovine viral diarrhea virus infec-tion on fertility of dairy heifers // Theriogenology. - 2004. - Vol. 61 (6). - P. 1085-1099.
9. Grooms D.L. Reproductive consequences of infection with bovine viral diarrhea virus // Vet. Clin. North. Am Food Anim Pract. - 2004. - Vol. 20(1). - P. 5-19.
10. Relative associations of cattle movements, local spread, and biosecurity with bovine viral diarrhoea virus (BVDV) seropositivity in beef and dairy herds / M.C. Gates , M.E. Woolhouse , G.J. Gunn [et al.] // Prev Vet Med. 2013. - Vol. 112 (3-4). - P. 285-295.
11. Kelling C.L., Topliff C.L. Bovine maternal, fetal and neonatal responses to bovine viral diar-rhea virus infections // Biologicals. - 2013. - Vol. 41 (1). - P. 20-25.
12. Effect of Bovine Viral Diarrhea Virus on the ovarian functionality and in vitro reproductive performance of persistently infected heifers / E.A. González Altamiranda , Kaiser , N.C. Mucci [et al.] // Vet Microbiol. - 2013. - Vol. 165 (3-4). - P. 326-332.
13. Glotov A.G., Krasnov V.V., Glotova T.I. Effektivnost' vakcinacii pri profilak-tike abortov, vyzvannyh virusom diarei - bolezni slizistyh obolochek krupnogo ro-gatogo skota // Vestnik KrasGAU. - 2010. - № 2. - S. 89-94.
14. Griebel P.J. BVDV vaccination in North Ameri-ca: risks versus benefits // Anim Health Res Rev. - 2015. - Vol. 16 (1). - P. 27-32.
15. Effect of treatment with a cationic antiviral compound on acute infection with bovine viral diarrhea virus / B.W. Newcomer, M.S. Mar-ley, P.K. Galik [et al.] // Canadian Journal Vet-erinary Research. - 2013. - Vol. 77. - P. 170-176.
16. Ashmarin I.P., Vasil'ev N.N., Ambrosov V.A. Bystrye metody statisticheskoy ob-rabotki i planirovaniya eksperimentov. - L.: Izd-vo Leningrad. un-ta, 1974. - 76 s.
17. L'vov D.K. Medicinskaya virusologiya: ruko-vodstvo. - M.: OOO «Med. inform. agentst-vo», 2008. - 656 s.
